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Deep-layer Hydrated Acellular Dermal Matrix
CoriLuxeDL is a human acellular dermal allograft sourced from deep cut layer of human skin dermis. The epidermis has been physically removed. The proprietary processing effectively removes immunogenic cells and terminally sterilizes ADM with a sterility assurance level (SAL) of 10-6 while preserving the natural collagen microstructure.

Preservation of the Extracellular Matrix (ECM)

  • CoriLuxeDL is produced using proprietary methods that avoid harsh chemicals, which could compromise the microstructure by weakening the collagen network or cross-linking the tissue. The matrix component and structure of CoriLuxeDL were evaluated against unprocessed skin tissue and CoriLuxe using histology, immunohistochemistry, mechanical, and ELISA to assess the preservation of the extracellular matrix. It demonstrated that CoriLuxeDL is similar to that of native tissue in terms of the structure and bioactive components.
  • The basement membrane is physically removed, and the porous natural structure is preserved after processing. Surgeons do not need to identify the orientation of CoriLuxeDL.
  • Growth factor screening assay detected significant levels of bFGF, EGF-R, HGF, IGF, IGFBPs, PDGF, TGFa, TGFb1 & VEGF in CoriLuxeDL.
  • Glycosaminoglycans (GAGs) and Angiogenin were detected in CoriLuxe.
  • The tensile test shows that the deep cut layer is slightly less strong than the top layer from the same donor. However, testing across three donors revealed no statistically significant difference. Proprietary sterilization with low-dose precision ebeam irradiation to achieve a Sterility Assurance Level (SAL) of 10-6.
  • CoriLuxeDL is to be used for the repair or replacement of damaged or inadequate integumental tissue or for other homologous uses of human integument.

Fig. 1

H&E Staining CoriLuxeDL shows similar collagen structure to that of unprocessed Dermis

Fig. 2

Verhoeff-Van Gieson Staining CoriLuxe shows similar elastin fiber structure (dark grey/ black stains)

Fig. 3

Trichrome Staining CoriLuxe shows similar collagen fiber structure (dark blue stains

Fig. 4

Trichrome Staining CoriLuxe shows similar collagen fiber structure (dark blue stains)

Product Ordering Information

  • Code Description
  • CLD0404 CoriLuxeDL Deep-layer Hydrated Acellular Dermal Matrix 4×4 cm
  • CLD0407 CoriLuxeDL Deep-layer Hydrated Acellular Dermal Matrix 4×7 cm
  • CLD0412 CoriLuxeDL Deep-layer Hydrated Acellular Dermal Matrix 4×12 cm
  • CLD0510 CoriLuxeDL Deep-layer Hydrated Acellular Dermal Matrix 5×10 cm
  • CLD0612 CoriLuxe DL Deep-layer Hydrated Acellular Dermal Matrix 6×12 cm
  • CLD0812 CoriLuxe DL Deep-layer Hydrated Acellular Dermal Matrix 8×12 cm
  • CLD1010 CoriLuxe DL Deep-layer Hydrated Acellular Dermal Matrix 10×10 cm
  • CLD1212 CoriLuxeDL Deep-layer Hydrated Acellular Dermal Matrix 12×12 cm
  • CLD1616 CoriLuxeDL Deep-layer Hydrated Acellular Dermal Matrix 16×16 cm
  • CLD1620 CoriLuxeDL Deep-layer Hydrated Acellular Dermal Matrix 16×20 cm
  • CLD2020 CoriLuxeDL Deep-layer Hydrated Acellular Dermal Matrix 20×20 cm
  • CLD0404-TN CoriLuxeDL Deep-layer Hydrated Acellular Dermal Matrix Thin 4x4cm
  • CLD0510-TN CoriLuxeDL Deep-layer Hydrated Acellular Dermal Matrix Thin 5x10cm
  • CLD1012-TN CoriLuxeDL Deep-layer Hydrated Acellular Dermal Matrix Thin 10x12cm
  • CLDM0404 CoriLuxeDL Deep-layer Meshed Hydrated Acellular Dermal Matrix 4x4cm
  • CLDM0407 CoriLuxeDL Deep-layer  Meshed Hydrated Acellular Dermal Matrix 4x7cm
  • CLDM0510 CoriLuxeDL Deep-Layer  Meshed  Hydrated Acellular Dermal Matrix 5x10cm
  • CLDM1212 CoriLuxeDL Deep-layer  Meshed Hydrated Acellular Dermal Matrix 12x12cm
  • CLDM1018 CoriLuxeDL Deep-layer  Meshed Hydrated Acellular Dermal Matrix 10x18cm 
  • CLDM1616 CoriLuxeDL Deep-layer  Meshed Hydrated Acellular Dermal Matrix 16x16cm
  • CLDM1620 CoriLuxeDL Deep-layer  Meshed Hydrated Acellular Dermal Matrix 16x20cm
  • CLDM2020 CoriLuxeDL Deep-layer  Meshed Hydrated Acellular Dermal Matrix 20x20cm
  • CLDM0404-TN CoriLuxeDL Deep-layer Meshed Hydrated Acellular Dermal Matrix Thin 4x4cm
  • CLDM0510-TN CoriLuxeDL Deep-layer Meshed Hydrated Acellular Dermal Matrix Thin 5x10cm
  • CLDM1012-TN CoriLuxeDL Deep-layer Meshed Hydrated Acellular Dermal Matrix Thin 10x12cm

References

  1. Badylak, S. F., et al. Extracellular matrix as a biological scaffold material: structure and function. Acta biomaterialia, 5(1), 1-13.
  2. Badylak, S. F. et al. The extracellular matrix as a scaffold for tissue reconstruction. In Seminars in cell & developmental biology (Vol. 13, No. 5, pp. 377-383). Academic Press.
  3. Chung, L. et al. Key players in the immune response to biomaterial scaffolds for regenerative medicine. Advanced drug delivery reviews, 114, 184-192. 4:
  4. J. Hur, et al. Outcome Assessment According to the Thickness and Direction of the Acellular Dermal Matrix after Implant-Based Breast Reconstruction. Biomed Res Int. 2021 Nov 16;
  5. Londono, R. et al. Biologic scaffolds for regenerative medicine: mechanisms of in vivo remodeling. Annals of biomedical engineering, 43(3), 577-592.
  6. Salbach, J., et al. Regenerative potential of glycosaminoglycans for skin and bone. Journal of molecular medicine, 90(6), 625-635. 8:
  7. WY Han, et al. Acellular Dermal Matrix without Basement Membrane in Immediate Prepectoral Breast Reconstruction: A Randomized Controlled Trial. Plast Reconstr Surg . 2024 Oct 1;154(4):649e-655e.
  8. Wen, J., et al. Applications of differential scanning calorimetry for thermal stability analysis of proteins: qualification of DSC. Journal of pharmaceutical sciences, 101(3), 955-964.
  9. Xiao SC, et al. The role of pores in acellular dermal matrix substitute. Ann Burns Fire Disasters. 2006;19(4):192-195

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