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Bio-Reign 3D™ BONE GRAFT SUBSTITUTE

Next Generation Bone Graft Substitute

Bio-Reign 3D™ is a non-mineralized, synthetic bone void filler created from leading edge hyper-crosslinked carbohydrate polymer technology. When placed in direct contact with patient bone, Bio-Reign 3D™ supports and guides the ingrowth of new bone across the graft site and is resorbed as the healing process occurs.

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Highly Porous

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Biodegradeable

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Biocompatible

A REVOLUTIONARY OSTEOBIOLOGIC
Bio-Reign 3D™ provides the ideal microenvironment for cell proliferation and vascularization leading to regeneration of healthy bone.

Radiolucent

Bio-Reign 3D™ is radiolucent upon implantation and becomes radiopaque as fusion occurs. This enables visualization of real-time fusion and healing, as well as early identification of pseudoarthrosis.

Osteoconductive

Bio-Reign 3D™ provides a physical scaffolding for cellular infiltration and proliferation. Its interconnected pores support and guide the ingrowth of new bone.

Synthetic

Bio-Reign 3D™ has no risk of disease transmission. The consistent quality of Bio-Reign 3D™ allows surgeons to easily manipulate and maximize direct contact with viable host bone.

Degradation
Profile Matches Bone
Formation

Bio-Reign 3D™ is replaced by newly formed bone following the natural course of repair and regeneration.

Standardized Pore Sizes

Overall Porosity: 75-95%
Macropores: 100 μm – 500 μm
Micropores: < 100 μm

Excellent Handling Characteristics

Bio-Reign 3D™ compressibility and tensile strength allow it to be gently packed in to fill a void or sutured in place.

Superior Performance in Three Configurations
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Granules

Available in 5 cc, 10 cc,
20 cc, and 30 cc volumes

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Sheets

Available in 25-75 mm length and
3 mm thickness

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Blocks

Available in 6-14 mm width sizes