Description and Intended Use:
MAXX-Cell is designed to obtain multiple small-volume bone marrow aspirations from a single access site without centrifugation.
Indicated for use in the aspiration of bone marrow and autologous blood.
Indicated for use in the aspiration of bone marrow and autologous blood.
Traditional Bone Marrow Aspiration:
Conventional marrow aspiration relies on withdrawing larger volumes through a stationary needle position.2 As aspiration continues, marrow spaces can become progressively infiltrated by peripheral blood, reducing the concentration of marrow-derived progenitor cells within the collected sample.2 For this reason, published literature has emphasized the importance of obtaining small-volume aspirations from multiple marrow locations whenever possible.2
Maxx-Cell® Difference:
The Maxx-Cell aspiration system uses a closed-tip aspiration cannula with side aspiration ports. After each small-volume draw, the aspiration cannula is mechanically repositioned within the marrow space by rotating the device, exposing the side ports to a new marrow location while maintaining a single cortical entry site. This allows sequential sampling from multiple areas of the marrow cavity through one insertion point and without the need for centrifugation.1
Aspiration can be performed through percutaneous technique or exposed iliac crest.
In a peer-reviewed study published in the Journal of Translational Medicine, the Marrow Cellution® aspiration method produced:
- Average CFU-F concentrations of 2,885 CFU-F/mL1
- Average total nucleated cell concentrations of 35.2 million cells/mL1l.
- Average CFU-F concentrations of 2,885 CFU-F/mL1
- Demonstrated significantly higher CFU-F concentrations than those observed in the evaluated centrifugation-based bone marrow concentration systems1
- CD34+ and CD117+ cell concentrations that were comparable to or greater than those reported for the evaluated systems (Scarpone et al)1
Results derived from a 30-patient case series and direct comparison studies reported by Scarpone et al., 2019.
Clinically Relevant Features:
Single Access, Multiple Sampling Locations
Maxx-Cell® utilizes a closed-tip, side-port aspiration cannula that can be repositioned after each draw, allowing sequential sampling from multiple marrow locations through a single cortical entry point.1
Optimized Aspiration Approach
Maxx-Cell® is designed around established bone marrow aspiration principles that emphasize sequential small-volume sampling from multiple marrow locations. Published research has shown that these techniques may help reduce peripheral blood dilution and improve aspirate quality.2
Point-of-Care Efficiency
Maxx-Cell® enables collection and direct use of bone marrow aspirate without centrifugation, simplifying workflow and reducing procedural steps in both surgical and office-based settings.1
Streamlined Workflow
By eliminating centrifugation, Maxx-Cell® removes the setup, processing, and cleanup steps associated with bone marrow concentration systems, creating a more streamlined aspiration workflow.3
Maintains a Sterile Workflow
Collection and delivery can be performed entirely within the sterile field, minimizing handling steps and supporting established sterile technique throughout the procedure.1,3
Maximizes Aspirate Utilization
Unlike processing systems that separate and concentrate selected components of the harvest, Maxx-Cell® is designed to collect bone marrow aspirate without additional processing, allowing the aspirate to be used directly for clinical application.3
Maxx-Cell® Enhanced Kit Components
Maxx-Cell® offers a range of kit components designed to support bone marrow aspiration procedures
PRODUCT ORDERING
- Code Description
- MXC-1 Maxx-Cell Bone Marrow Aspiration Kit 11cm
- MXC-2 Maxx-Cell Bone Marrow Aspiration Kit 11cm w Accessories
- MXC-3 Maxx-Cell Bone Marrow Aspiration Kit 11cm with Biopsy Needle
REFERENCES
1. Scarpone M, Kuebler D, Chambers A, De Filippo CM, Amatuzio M, Ichim TE, Patel AN, Caradonna E. Isolation of clinically relevant concentrations of bone marrow mesenchymal stem cells without centrifugation. Journal of Translational Medicine. 2019;17(10). doi:10.1186/s12967-018-1750-x.
2. Patterson TE, Boehm C, Nakamoto C, Rozic R, Walker E, Piuzzi NS, Muschler GF. The efficiency of bone marrow aspiration for the harvest of connective tissue progenitors from the human iliac crest. Journal of Bone and Joint Surgery Am. 2017;99(19):1673-1682. doi:10.2106/JBJS.17.00094.
3. Harrell DB, Purita JR, Gonzalez R, Liriano L. Novel Technology to Increase Concentrations of Stem and Progenitor Cells in Marrow Aspiration. White Paper. Endocellutions Corp and Ranfac Corp; 2016.
2. Patterson TE, Boehm C, Nakamoto C, Rozic R, Walker E, Piuzzi NS, Muschler GF. The efficiency of bone marrow aspiration for the harvest of connective tissue progenitors from the human iliac crest. Journal of Bone and Joint Surgery Am. 2017;99(19):1673-1682. doi:10.2106/JBJS.17.00094.
3. Harrell DB, Purita JR, Gonzalez R, Liriano L. Novel Technology to Increase Concentrations of Stem and Progenitor Cells in Marrow Aspiration. White Paper. Endocellutions Corp and Ranfac Corp; 2016.