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Hydrated Acellular Dermal Matrix

Preservation of the Extracellular Matrix (ECM)
The extracellular matrix components and their natural structure in unprocessed dermal tissue are crucial for facilitating proper cell-cell interactions and overall tissue function. To ensure robust tissue remodeling and regeneration following surgical procedures using acellular dermal matrix allografts, it is essential that the acellular dermal matrix maintains the intact extracellular matrix structure. CoriLuxe is produced using proprietary methods that avoid harsh chemicals, which could compromise the microstructure by weakening the collagen network or cross-linking the tissue. The matrix component and structure of CoriLuxe were evaluated against unprocessed skin tissue using histology, immunohistochemistry, transmission electron microscopy, and gel electrophoresis to assess the preservation of the extracellular matrix. †

Summary

CoriLuxe is a pre-hydrated, human acellular dermal matrix allograft sourced from human skin. It undergoes aseptic processing and terminal sterilization to maintain the natural collagen microstructure, while effectively removing immunogenic cells and epidermis. *

CoriLuxe is engineered to preserve the structural integrity of extracellular matrix components, including collagen, elastin, and glycosaminoglycan (GAG). These components create an ideal microenvironment for tissue remodeling in regenerative medicine applications, providing mechanical strength, collagen integrity, and bioactive elements akin to unprocessed dermis.1 Additionally, it maintains the basement membrane to prevent adhesion formation and a basement membrane complex of blood vessels to promote angiogenesis.2

Our proprietary methodology for processing and sterilizing grafts utilizes low-dose precision gamma irradiation to achieve a Sterility Assurance Level (SAL) of 10-6. As a sterile graft, CoriLuxe offers an additional layer of safety critical for successful surgical procedures by reducing the risk of adverse immune responses and capsular formation. Our unique processing technique preserves the essential characteristics of the natural dermal matrix, ensuring CoriLuxe closely resembles unprocessed dermis. The matrix properties of CoriLuxe are rigorously evaluated through both in vitro and in vivo studies. *†

Product Ordering Information

  • Code Description
  • CL0404 CoriLuxe Meshed Hydrated Acellular Dermal Matrix 4 x 4 cm
  • CL0407 CoriLuxe Meshed Hydrated Acellular Dermal Matrix 4 x 7 cm
  • CL0510 CoriLuxe Meshed Hydrated Acellular Dermal Matrix 5 x 10 cm
  • CL1212 CoriLuxe Meshed Hydrated Acellular Dermal Matrix 12 x 12 cm
  • CL1018 CoriLuxe Meshed Hydrated Acellular Dermal Matrix 10 x 18 cm
  • CL1821 CoriLuxe Meshed Hydrated Acellular Dermal Matrix 18 x 21 cm

References

  1. Londono, R., & Badylak, S. F. (2015). Biologic scaffolds for regenerative medicine: mechanisms of in vivo remodeling. Annals of biomedical engineering, 43(3), 577-592.
  2. Breitkreutz, D., Koxholt, I., Thiemann, K., & Nischt, R. (2013). Skin basement membrane: the foundation of epidermal integrity—BM functions and diverse roles of bridging molecules nidogen and perlecan. BioMed research international, 2013.

† Berkeley Biologics data on file
*Instructions for Use

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