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Advanced Bone Grafting & Fusion Convenience Kit

Advanced Cell is a new advanced bone grafting and fusion convenience kit that offers multiple solutions to achieve optimal results in a variety of settings. Advanced Cell offers 3 unique technologies all in one convenience kit that have the ability to enhance clinical outcomes.
3 Technologies in 1 Kit
Maxx-Cell® has created a new gold standard in bone marrow aspiration therapy for various uses in orthopedics, sports medicine and pain management. Deliver the highest, most pure enriched form of bone marrow aspirate without the need for centrifugation. Maximize cell count yields and CFU’s while minimizing peripheral blood dilution. “Maxx-Cell® uses its technology to harvest high quality stem and progenitor cells from various levels within the marrow space, limiting peripheral blood contamination.”
Aspirating Bone Marrow from multiple locations allows for the maximum amount of progenitor stem cells are collected, without the dilution or collection of peripheral blood.

Next Generation Organic Bone Graft Substitute

Bio-Reign 3D™ provides a physical interconnected and highly porous matrix that supports osteogenic cellular infiltration, leading to new bone growth. BIO-REIGN 3D™ has a truly unique degradation profile that matches bone formation. BIO-REIGN 3D™ is replaced by newly formed bone following the natural course of repair and regeneration. BIO-REIGN 3D™ has excellent compressibility, tensile strength and handling characteristics to provide superior moldability and malleability of the graft. BIO-REIGN 3D™ can additionally be sutured in place to prevent graft migration.

Highly Porous
Endochondral Bone
Formation
Biocompatible

“Numerous natural and synthetic biomaterials have been proposed as 3D scaffolds for tissue engineering, including collagen, hyaluronic acid, decellularized extracellular matrices, polylactic acid and polyglycolic acid… However, the ideal material must be biocompatible, biodegradable, bioabsorbable, nontoxic and noninflammatory. Bio-Reign 3D™ is the final result of this ideal 3D scaffold.”

Charles Lee

CEO of Molecular Matrix

Superior Performance In Three Configurations

Granules

Available in 5 cc, 10 cc, 20 cc, and 30 cc volumes

Sheets

Available in 25-75 mm length and 3 mm thickness

Blocks

Available in 6-14 mm width size

A Revolutionary Osteobiologic

Bio-Reign 3D™ provides the ideal microenvironment for cell proliferation and vascularization leading to regeneration of healthy bone.

Radiolucent

Bio-Reign 3D™ is radiolucent upon implantation and becomes radiopaque as fusion occurs. This enables visualization of real-time fusion and healing, as well as early identification of pseudoarthrosis.

Osteoconductive

Bio-Reign 3D™ provides a physical scaffolding for cellular infiltration and proliferation. Its interconnected pores support and guide the ingrowth of new bone.

Synthetic

Bio-Reign 3D™ has no risk of disease transmission. The consistent quality of Bio-Reign 3D™ allows surgeons to easily manipulate and maximize direct contact with viable host bone.

Degradation Profile Matches Bone Formation

Bio-Reign 3D™ is replaced by newly formed bone following the natural course of repair and regeneration.

Standardized Pore Sizes

Overall Porosity:75-95%
Macropores:100μm-500μm
Micropores:<100μm

Excellent Handling Characteristics

Bio-Reign 3D™ compressibility and tensile strength allow it to be gently packed in to fill a void or sutured in place.

Autograft Harvesting System

8 gauge bone marrow biopsy needle used for percutaneous trephine extraction of autogenous bone marrow/cancellous bone dowels.
Bone marrow aspiration and trephine extraction of cancellous bone are considered minimally invasive techniques compared to open methods of bone extraction and has been documented to have less donor site morbidity than open procedures.(1,2,3).
Research demonstrates the enhanced survival of a bone graft as long as its primary blood supply is preserved. A living bone graft will shorten the time for bony onion because the reconstructed bone is comparable to a bone with a double fracture. (6,7)
Allogeneic or synthetic bone chips hydrated with marrow can be packed around the living bone graft/core to accelerate anastomosis into the graft and minimize morbidity. (6,7)

SOURCES

  1. https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD011783/full accessed on 13 Nov 2018.
  2. Missiuna PC, Gandhi HS, Farrokhyar F, Harnett BE, Dore EM, Roberts B. Anatomically safe and minimally invasive transcrestal technique for procurement of autogenous cancellous bone graft from the mid-iliac crest. Can J Surg. 2011;54(5):327-32.
  3. Hernigou P, Descroches A, Quennec S, Flousat Lachaniette CH, Poignard A, Allain J, Chevallier N, Rouard H. Morbidity of graft harvesting versus bone marrow aspiration in cell regenerative therapy. Int Orthop. 2014 Sep;38(9):1855-60
  4. Block JE. The role and effectiveness of bone marrow in osseous regeneration. Med Hypotheses. 2005;65(4):740-7.
  5. Wang W, Yeung K. Bone grafts and biomaterials substitutes for bone defect repair. A review. Bioactive Materials. 2017;2(4):224-227.
  6. Bleuming SA, He XC, Kodach LL, Hardwick JC, Koopman FA, Ten Kate FJ, van Deventer SJ, Hommes DW, Peppelenbosch MP, Offerhaus GJ, Li L, van den Brink GR (Sep 2007).
“Bone morphogenetic protein signaling suppresses tumorigenesis at gastric epithelial transition zones in mice”. Cancer Research. 67 (17): 8149–55.
  7. Ostrup et al Distant transfer of a free, living bone graft by micro-vascular anastomoses. An experimental study. Plast Reconstr. Surg. 1974 Sep; 54(3): 274-85

Explore our Entire Product Line

Autologous Advanced Biologics

Cellular Bone Graft

Traditional Bone Grafts

Advanced Synthetics

Wound Care

About Royal

Royal is a pioneering leader in orthobiologic and wound care research and development. Royal’s commitment lies in delivering top-tier, innovative biologic solutions that enhance the healing process and improve patients' quality of life. Royal places patient well-being at the center of its mission, offering exceptional solutions to address a variety of complex needs.

At Royal, our mission is driven by patient-centered care, innovation and excellence, and integrity and compassion.
Royal provides a comprehensive array of products tailored to meet the varied needs of the orthobiologic and wound care industry.

As a rapidly expanding force in the industry, Royal is continuously developing and launching new products and solutions that set benchmarks for quality, effectiveness, and patient outcomes. Royal’s commitment to research and innovation keeps it at the forefront of the industry, helping to shape the future of healthcare and improving lives.