Abiomend Xplus Membrane is an advanced, crosslinked, chorion-free amniotic tissue designed to support wound healing and tissue regeneration.5 The crosslinking process makes Abiomend Xplus particularly useful in long-term wound coverage and structural support, distinguishing it from non-crosslinked amniotic membranes that degrade quicker.3
Product Features
Single-Layer Technology
Chorion-Free: Minimizes immunogenicity
Size Option Versatility
Storage & Handling: Stable at ambient room temperature (15-30°C or 59-86°F) until use
CROSSLINKED Features
- Increased Strength & Stability: Crosslinking strengthens the extracellular matrix (ECM) by creating covalent bonds between collagen fibers, improving its mechanical properties.5
- Extended Resorption Time: The process slows down the natural degradation of the tissue, allowing it to remain in the body longer for sustained therapeutic effects.3
- Improved Biocompatibility: Crosslinked membranes retain essential growth factors while reducing the risk of rapid breakdown or host rejection.1,3,5
- Enhanced Wound Protection: Provides a more robust and resilient barrier for wound healing and tissue regeneration.4
Why Choose Abiomend Xplus?
- Crosslinked: Enhances structural integrity and durability.3,5
- Ethically Sourced & Safe: Donor tissues are recovered with maternal consent, using stringent screening and aseptic processing to meet FDA and CLIA standards.
- Rich in Growth Factors: Contains key growth factors, cytokines, and extracellular matrix proteins vital for wound healing.1,3
- Supports Natural Healing: Offers anti-inflammatory, antibacterial, and anti-fibrotic properties to promote tissue regeneration.4
- Flexible & Adaptable: Provides greater tensile strength, shape manipulation, and controlled resorption for various clinical applications.3
Key growth factors found in Abiomend xplus:
- Fibroblast Growth Factor (FGF) 1,3
- Epidermal Growth Factor (EGF) 1,3
- Platelet Derived Growth Factor (PDGF) A & B 1,3
- Vascular Endothelial Growth Factor (VEGF) 1,3
- Transforming Growth Factor beta (TBFβ) 1,3
Extracellular matrix elements found in Ambiomend xplus:
- Collagen Types I, III, IV, V and VII 4
- Laminin
- Fibronectin
- Tissue Inhibitors of Metalloproteinases (TIMPs)
- Proteoglycans
- Hyaluronic Acid (HA)
Applications:
- Chronic wounds (diabetic ulcers, pressure ulcers)2
- Surgical wounds
- Burns and trauma wounds 2
- Ophthalmic procedures
- Orthopedic and sports medicine
ORDERING
INFORMATIONN – Q4355
- Code Description
- ABXM-11 Single Layer Crosslinked Amniotic Membrane 1×1 cm
- ABXM-22 Single Layer Crosslinked Amniotic Membrane 2×2 cm
- ABXM-23 Single Layer Crosslinked Amniotic Membrane 2×3 cm
- ABXM-33 Single Layer Crosslinked Amniotic Membrane 3×3 cm
- ABXM-44 Single Layer Crosslinked Amniotic Membrane 4×4 cm
- ABXM-46 Single Layer Crosslinked Amniotic Membrane 4×6 cm
- ABXM-48 Single Layer Crosslinked Amniotic Membrane 4×8 cm
- ABXM-713 Single Layer Crosslinked Amniotic Membrane 7.5×13 cm
- ABXM-1015 Single Layer Crosslinked Amniotic Membrane 10×15 cm
- ABXM-1020 Single Layer Crosslinked Amniotic Membrane 10×20 cm
REFERENCES:
1) Complements and the Wound Healing Cascade: An Updated Review. Hani Sinno and Satya Prakash. Plast Surg Int. 2013; 2013: 146764
2) The Grafting of Preserved Amniotic Membrane to Burned and Ulcerated Surfaces, Substituting Skin Grafts: A Preliminary Report. Maximilian Stern. JAMA. 1913; 60(13): 973-974
3) Growth factors and cytokines in wound healing. Barrientos S, Stojadinovic 0, Golinko MS, Brem H, Tomic-Canic M. Wound Repair Regen. 2008; 16(5):585-601
4) Immunological characteristics of amniotic epithelium. Hori J, Wang M, Kamiya K, Takahashi H, Sakuragawa N. Cornea. 2006; 25(10): S53-58
5) Delgado LM, Bayon Y, Pandit A, Zeugolis DI. To cross-link or not to cross-link? Cross-linking associated foreign body response of collagen-based devices. Tissue Eng Part B Rev. 2015 Jun;21(3):298-313. doi: 10.1089/ten.TEB.2014.0290. Epub 2015 Mar 12. PMID: 25517923; PMCID: PMC4442559.
2) The Grafting of Preserved Amniotic Membrane to Burned and Ulcerated Surfaces, Substituting Skin Grafts: A Preliminary Report. Maximilian Stern. JAMA. 1913; 60(13): 973-974
3) Growth factors and cytokines in wound healing. Barrientos S, Stojadinovic 0, Golinko MS, Brem H, Tomic-Canic M. Wound Repair Regen. 2008; 16(5):585-601
4) Immunological characteristics of amniotic epithelium. Hori J, Wang M, Kamiya K, Takahashi H, Sakuragawa N. Cornea. 2006; 25(10): S53-58
5) Delgado LM, Bayon Y, Pandit A, Zeugolis DI. To cross-link or not to cross-link? Cross-linking associated foreign body response of collagen-based devices. Tissue Eng Part B Rev. 2015 Jun;21(3):298-313. doi: 10.1089/ten.TEB.2014.0290. Epub 2015 Mar 12. PMID: 25517923; PMCID: PMC4442559.
Explore our Entire Product Line
Autologous Advanced Biologics
Advanced Synthetics