Bio-Reign® 3D | Royal Biologics

Bio-Reign® 3D Bone Graft Substitute

Bio-Reign® 3D provides a physical interconnected and highly porous matrix that supports osteogenic cellular infiltration leading to new bone growth. Bio-Reign® 3D has a truly unique degradation profile that matches bone formation. Bio-Reign® 3D is replaced by newly formed bone following the natural course of repair and regeneration. Bio-Reign® 3D has excellent compressibility, tensile strength, and handling characteristics to provide superior moldability and malleability of the graft. Bio-Reign® 3D can additionally be sutured in place to prevent graft migration.

Next Generation Bone Graft Substitute

Bio-Reign® 3D is a non-mineralized, synthetic bone void filler created from leading edge hyper-crosslinked carbohydrate polymer technology. When placed in direct contact with patient bone, Bio-Reign® 3D supports and guides the ingrowth of new bone across the graft site and is resorbed as the healing process occurs.

Highly Porous

Biodegradeable

Biocompatible

A Revoluntionary Osteobiologic

Bio-Reign® 3D provides the ideal microenvironment for cell proliferation and vascularization leading to regeneration of healthy bone.

Radiolucent

Bio-Reign® 3D is radiolucent upon implantation and becomes radiopaque as fusion occurs. This enables visualization of real-time fusion and healing, as well as early identification of pseudoarthrosis.

Osteoconductive

Bio-Reign® 3D provides a physical scaffolding for cellular infiltration and proliferation. Its interconnected pores support and guide the ingrowth of new bone.

Synthetic

Bio-Reign® 3D has no risk of disease transmission. The consistent quality of Bio-Reign® 3D allows surgeons to easily manipulate and maximize direct contact with viable host bone.

Degradation Profile Matches Bone Formation

Bio-Reign® 3D is replaced by newly formed bone following the natural course of repair and regeneration.

Standardized
Pore Sizes

Overall Porosity: 75-95%
Macropores: 100 μm – 500 μm
Micropores: < 100 μm

Excellent Handling Characteristics

Bio-Reign® 3D compressibility and tensile strength allow it to be gently packed in to fill a void or sutured in place.

Superior Performance in Three Configurations

Granules

Available in 5 cc, 10 cc, 20 cc, and 30 cc volumes

Sheets

Available in 25-75 mm length and 3 mm thickness

Blocks

Available in 6-14 mm width sizes

Explore our Entire Product Line

Autologous Advanced Biologics

Cellular Bone Graft

Magnus®

Traditional Bone Grafts

Maxx Fuse

Advanced Synthetics

Wound Care

About Royal

Royal is a pioneering leader in orthobiologic and wound care research and development. Royal’s commitment lies in delivering top-tier, innovative biologic solutions that enhance the healing process and improve patients' quality of life. Royal places patient well-being at the center of its mission, offering exceptional solutions to address a variety of complex needs.

At Royal, our mission is driven by patient-centered care, innovation and excellence, and integrity and compassion. Royal provides a comprehensive array of products tailored to meet the varied needs of the orthobiologic and wound care industry.

As a rapidly expanding force in the industry, Royal is continuously developing and launching new products and solutions that set benchmarks for quality, effectiveness, and patient outcomes. Royal’s commitment to research and innovation keeps it at the forefront of the industry, helping to shape the future of healthcare and improving lives.