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Cryo-Cord™ is a cryopreserved placental umbilical cord allograft that may be used as an anatomical barrier in numerous clinical applications. Cryo-Cord retains the natural properties of placental tissue including nutrient-rich growth factors, cytokines, endogenous cells, and Wharton’s Jelly.
About Cryo-Cord™
  • Placental tissue acts as an immune-privileged protective barrier during fetal development 1
  • Cryo-Cord™ is applied as an anatomical barrier that helps provide mechanical protection while retaining endogenous growth factors (Figure 1) .1,2,4
  • The Cryo-Cord™ proprietary process preserves the natural properties of placental umbilical cord tissue, maintaining inherent levels of key extracellular matrix molecules, including proteins, carbohydrates, growth factors, and cytokines.
  • Cryo-Cord™ contains viable endogenous cells cryopreserved in a proprietary DMSO-free cryoprotectant (Figure 2) .5
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Fresh Umbilical Cord

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Cryo-Cord Post-Thaw

Figure 2: Viable Cells in Cryo-Cord5

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Fresh Umbilical Cord

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Post-Thaw

Figure 3: Cryo-Cord Histology

Safety and Versatility
  • Placental tissue is recovered from healthy mothers who have undergone C-section delivery
  • Cryo-Cord™ is aseptically processed in accordance with FDA regulations and AATB standards
  • Placental tissue has been used for over 100 years with well-documented clinical success. 3
  • No rinsing or decanting steps required during preparation
  • Storage at -65°C or colder
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Potential Clinical Applications
  • Spine & Neurosurgery
  • Dermatology
  • Foot & Ankle
  • Ophthalmology
  • Wound Care
  • Oral Surgery
  • Burn Care

References:

  • 1. Rowlatt, U. (1979). Intrauterine wound healing in a 20-week human fetus. Virchows Arch A Pathol Anat Histol, 381(3), 353–361.
  • 2. Coolen, N.A. et al. (2010). Comparison between human fetal and adult skin. Archives of Dermatological Research, 302(1), 47–55.
  • 3. Fairbairn, N.G. et al. (2014). The clinical applications of human amnion in plastic surgery, 67, 662-675.
  • 4. Niknejad H, Peirovi H, Jorjani M, et al. Properties of the amniotic membrane for potential use in tissue engineering. Eur Cell Mater. 2008;15:88-89.
  • 5. Data on file at Vivex Biologics, Inc.